| MACC1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | MACC1, 7A5, SH3BP4L, metastasis associated in colon cancer 1, MET transcriptional regulator, MET transcriptional regulator MACC1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 612646 MGI: 2685113 HomoloGene: 18813 GeneCards: MACC1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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MACC1, MET transcriptional regulator is a protein that in humans is encoded by the MACC1 gene.[5]
Function
MACC1 is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (HGFR) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival.[6]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000183742 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041886 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: MACC1, MET transcriptional regulator". Retrieved 2018-08-02.
- ↑ Stein U, Walther W, Arlt F, Schwabe H, Smith J, Fichtner I, et al. (January 2009). "MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis". Nature Medicine. 15 (1): 59–67. doi:10.1038/nm.1889. PMID 19098908. S2CID 8854895.
Further reading
- Kokoszyńska K, Kryński J, Rychlewski L, Wyrwicz LS (2009). "Unexpected domain composition of MACC1 links MET signaling and apoptosis" (PDF). Acta Biochimica Polonica. 56 (2): 317–23. doi:10.18388/abp.2009_2464. PMID 19499089.
- Stein U, Smith J, Walther W, Arlt F (August 2009). "MACC1 controls Met: what a difference an Sp1 site makes". Cell Cycle. 8 (15): 2467–9. doi:10.4161/cc.8.15.9018. PMID 19556890.
- Stein U, Dahlmann M, Walther W (January 2010). "MACC1 - more than metastasis? Facts and predictions about a novel gene". Journal of Molecular Medicine. 88 (1): 11–8. doi:10.1007/s00109-009-0537-1. PMID 19787327. S2CID 13225629.
- Shirahata A, Shinmura K, Kitamura Y, Sakuraba K, Yokomizo K, Goto T, et al. (July 2010). "MACC1 as a marker for advanced colorectal carcinoma". Anticancer Research. 30 (7): 2689–92. PMID 20682999.
- Shirahata A, Sakata M, Kitamura Y, Sakuraba K, Yokomizo K, Goto T, et al. (September 2010). "MACC 1 as a marker for peritoneal-disseminated gastric carcinoma". Anticancer Research. 30 (9): 3441–4. PMID 20944120.
- Shimokawa H, Uramoto H, Onitsuka T, Chundong G, Hanagiri T, Oyama T, Yasumoto K (April 2011). "Overexpression of MACC1 mRNA in lung adenocarcinoma is associated with postoperative recurrence". The Journal of Thoracic and Cardiovascular Surgery. 141 (4): 895–8. doi:10.1016/j.jtcvs.2010.09.044. PMID 21093878.
- Galimi F, Torti D, Sassi F, Isella C, Corà D, Gastaldi S, et al. (May 2011). "Genetic and expression analysis of MET, MACC1, and HGF in metastatic colorectal cancer: response to met inhibition in patient xenografts and pathologic correlations". Clinical Cancer Research. 17 (10): 3146–56. doi:10.1158/1078-0432.CCR-10-3377. hdl:2318/110677. PMID 21447729.
- Shirahata A, Fan W, Sakuraba K, Yokomizo K, Goto T, Mizukami H, et al. (March 2011). "MACC 1 as a marker for vascular invasive hepatocellular carcinoma". Anticancer Research. 31 (3): 777–80. PMID 21498695.
- Chundong G, Uramoto H, Onitsuka T, Shimokawa H, Iwanami T, Nakagawa M, et al. (April 2011). "Molecular diagnosis of MACC1 status in lung adenocarcinoma by immunohistochemical analysis". Anticancer Research. 31 (4): 1141–5. PMID 21508357.
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