Singles
2021 Challenger de Santiago III
Champion	Sebastián Báez
Runner-up	Felipe Meligeni Alves
Score	3–6, 7–6(8–6), 6–1

Juan Pablo Varillas was the defending champion^[1] but lost in the quarterfinals to Marcelo Tomás Barrios Vera.

Sebastián Báez won the title after defeating Felipe Meligeni Alves 3–6, 7–6^(8–6), 6–1 in the final.

Seeds

Draw

Finals

	Semifinals							Final
	5	Sebastián Báez	3	6	6
	6	Marcelo Tomás Barrios Vera	6	3	4
								5	Sebastián Báez	3	78	6
									Felipe Meligeni Alves	6	66	1
		Felipe Meligeni Alves	6	6
		Matheus Pucinelli de Almeida	2	4

Top half

	First round							Second round							Quarterfinals							Semifinals
	1	JM Cerúndolo	6	6
		J Lenz	3	3				1	JM Cerúndolo	6	3	6
	WC	Benjamín Torres	3	4					P Cachin	4	6	2
		P Cachin	6	6											1	JM Cerúndolo	3	4
		JP Ficovich	6	6											5	S Báez	6	6
		G Oliveira	3	1					JP Ficovich	1	5
	Q	N Álvarez	5	3				5	S Báez	6	7
	5	S Báez	7	6																		5	S Báez	3	6	6
	3	JP Varillas	6	6																		6	MT Barrios Vera	6	3	4
		F Mena	4	2				3	JP Varillas	6	1	6
		D Svrčina	6	6					D Svrčina	4	6	4
	Q	D Hidalgo	2	0											3	JP Varillas	3	4
	Q	R Matos	2	6	4										6	MT Barrios Vera	6	6
	WC	D Fernández Flores	6	4	6			WC	D Fernández Flores	0	1
	LL	L Catarina	5	2				6	MT Barrios Vera	6	6
	6	MT Barrios Vera	7	6

Bottom half

	First round							Second round							Quarterfinals							Semifinals
	7	JI Londero	6	3	6
	Alt	G Lama	2	6	1			7	JI Londero	6	3	4
	Q	Oliver Crawford	66	3					F Meligeni Alves	2	6	6
		F Meligeni Alves	78	6												F Meligeni Alves	6	5	7
		N Jarry	62	4											PR	G Melzer	3	7	5
	PR	G Melzer	77	6				PR	G Melzer	6	6
		TA Tirante	6	4	6				TA Tirante	2	0
	4	T Seyboth Wild	4	6	2																		F Meligeni Alves	6	6
	8	E Couacaud	1	1																			M Pucinelli de Almeida	2	4
		M Pucinelli de Almeida	6	6					M Pucinelli de Almeida	3	6	6
		N Kicker	6	6					N Kicker	6	2	4
	WC	M Soto	3	0												M Pucinelli de Almeida	77	2	6
	Alt	N Chappell	3	4											2	F Cerúndolo	63	6	4
	Alt	H Casanova	6	6				Alt	H Casanova	2	5
	Alt	F Díaz Acosta	4	0				2	F Cerúndolo	6	7
	2	F Cerúndolo	6	6

References

External links

• Main draw
• Qualifying draw