Singles
2021 Challenger Ciudad de Guayaquil
Champion	Alejandro Tabilo
Runner-up	Jesper de Jong
Score	6–1, 7–5

Francisco Cerúndolo was the defending champion^[1] but lost in the second round to Gonçalo Oliveira.

Alejandro Tabilo won the title after defeating Jesper de Jong 6–1, 7–5 in the final.

Seeds

Draw

Finals

	Semifinals							Final
		Alejandro Tabilo	6	77
	6	Thiago Seyboth Wild	2	62
									Alejandro Tabilo	6	7
									Jesper de Jong	1	5
		Jesper de Jong	7	6
	8	Tomás Martín Etcheverry	5	3

Top half

	First round							Second round							Quarterfinals							Semifinals
	1	J Munar	4	2
		A Tabilo	6	6					A Tabilo	6	6
	WC	Á Guillén Meza	6	3	4				D King	3	1
		D King	0	6	6											A Tabilo	6	6
		G Oliveira	6	77												G Oliveira	4	3
		R Cid Subervi	3	61					G Oliveira	6	6
		V Kopřiva	7	2	3			5	F Cerúndolo	4	3
	5	F Cerúndolo	5	6	6																		A Tabilo	6	77
	4	S Báez	63	6	5																	6	T Seyboth Wild	2	62
		N Kicker	77	4	7				N Kicker	77	6
	Q	D Dutra da Silva	2	77	6			Q	D Dutra da Silva	65	3
		N Hardt	6	65	0											N Kicker	4	68
	Q	A González	6	6											6	T Seyboth Wild	6	710
	Alt	A Galarneau	2	4				Q	A González	62	0
		A Collarini	3	77	2			6	T Seyboth Wild	77	6
	6	T Seyboth Wild	6	63	6

Bottom half

	First round							Second round							Quarterfinals							Semifinals
	7	H Dellien	6	6
		P Krstin	4	2				7	H Dellien	1	0
		J de Jong	3	77	0				J de Jong	6	6
		G Andreozzi	6	64	0r											J de Jong	6	65	6
	Q	Facundo Juárez	3	6	6										3	DE Galán	2	77	3
	Alt	F Díaz Acosta	6	4	4			Q	F Juárez	4	3
		N Mejía	2	5				3	DE Galán	6	6
	3	DE Galán	6	7																			J de Jong	7	6
	8	TM Etcheverry	6	3	7																	8	TM Etcheverry	5	3
		R Quiroz	1	6	5			8	TM Etcheverry	6	3	77
	LL	N Álvarez Varona	2	6	6			LL	N Álvarez Varona	4	6	64
	WC	D Hidalgo	6	4	3										8	TM Etcheverry	6	6
	Q	N Álvarez	4	7	6										2/WC	F Bagnis	4	0
		TA Tirante	6	5	3			Q	N Álvarez	2	6	1
		H Casanova	2	2				2/WC	F Bagnis	6	4	6
	2/WC	F Bagnis	6	6

References

External links

• Main draw
• Qualifying draw