Singles
2021 Biella Challenger V
Champion	Juan Pablo Varillas
Runner-up	Guido Andreozzi
Score	6–3, 6–1

Daniel Masur was the defending champion^[1] but chose not to defend his title.

Juan Pablo Varillas won the title after defeating Guido Andreozzi 6–3, 6–1 in the final.

Seeds

Draw

Finals

	Semifinals							Final
	7	Juan Pablo Varillas	6	2	6
		Alexandre Müller	2	6	2
								7	Juan Pablo Varillas	6	6
								Q	Guido Andreozzi	3	1
	Q	Guido Andreozzi	7	6
	Alt	Andrea Collarini	5	2

Top half

	First round							Second round							Quarterfinals							Semifinals
	1	P Sousa	63	4
		J Menezes	77	6					J Menezes	7	2	6
	WC	H Međedović	7	77				WC	H Međedović	5	6	4
		R Bemelmans	5	64												J Menezes	4	3
	LL	D Kuzmanov	6	1	6										7	JP Varillas	6	6
		L Giustino	3	6	3			LL	D Kuzmanov	1	7	60
		A Giannessi	4	5				7	JP Varillas	6	5	77
	7	JP Varillas	6	7																		7	JP Varillas	6	2	6
	3	M McDonald	3	6	6																		A Müller	2	6	2
		JM Cerúndolo	6	4	3			3	M McDonald	77	2	4
	WC	L Vanni	67	0					L Mayer	60	6	6
		L Mayer	79	6												L Mayer	3	4
		Zh Zhang	4	6	6											A Müller	6	6
	Q	F Meligeni Alves	6	4	4				Zh Zhang	3	77	5
		A Müller	1	6	6				A Müller	6	64	7
	6	H Gaston	6	3	3

Bottom half

	First round							Second round							Quarterfinals							Semifinals
	8	G Soeda	2	1
	Q	M Marterer	6	6				Q	M Marterer	3	3
	Alt	J Clarke	7	6				Alt	J Clarke	6	6
	Q	V Galović	5	2											Alt	J Clarke	6	3	5
	Q	G Andreozzi	6	7											Q	G Andreozzi	3	6	7
		K Coppejans	2	5				Q	G Andreozzi	3	6	6
	LL	MT Barrios Vera	6	6				LL	MT Barrios Vera	6	3	3
	4	C-M Stebe	2	4																		Q	G Andreozzi	7	6
	5	F Gaio	63	77	6																	Alt	A Collarini	5	2
		P Lorenzi	77	64	2			5	F Gaio	6	6
		F Horanský	2	4					J Domingues	4	3
		J Domingues	6	6											5	F Gaio	6	4	1
	Alt	A Collarini	6	6											Alt	A Collarini	4	6	6
		A Bolt	2	2				Alt	A Collarini	6	7
	WC	S Napolitano	0	7	1			2	H Dellien	1	5
	2	H Dellien	6	5	6

References

• Main draw
• Qualifying draw