populous region around the city of Pittsburgh in Pennsylvania
The Pittsburgh Region is the most southwestern part of Pennsylvania. It is an area rich with history and scenery, home to the metropolitan area of Pittsburgh, old industrial towns, and some of the highest elevations in the state.
| Allegheny County the city of Pittsburgh and its immediate suburbs |
| Laurel Highlands Bedford, Cambria, Somerset, Fayette, and Westmoreland Counties |
| North Pittsburgh Region Armstrong, Beaver, Butler, Indiana, and Lawrence Counties |
| South Pittsburgh Region Washington and Greene Counties |
Pittsburgh and its surrounding area has a distinct regional identity and has historically been regarded as a transitional region within the Northeastern United States. The region's counties also fall within the borders of Appalachia as defined by the Appalachian Regional Commission. The City of Pittsburgh has been characterized as the "northern urban industrial anchor of Appalachia" which makes it an anomaly compared to much of Appalachia which has traditionally been characterized as southern, rural, and economically distressed.