Say It Ain't So, Joe may refer to:
- Say It Ain't So, Joe (opera), by Curtis K. Hughes, inspired by the 2008 United States vice-presidential debate
- "Say It Ain't So, Joe" (song), by Murray Head, 1975, and covered by Roger Daltrey, 1977
- "Say it ain't so, Joe", a phrase regarding Shoeless Joe Jackson
See also
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