Mpofu is a surname found in Southern Africa mainly in Zimbabwe and South Africa.
Mpofu is an African surname that may refer to:
- Christopher Mpofu (born 1985), Zimbabwean cricketer
- Dali Mpofu (born 1962), South African lawyer and politician
- Elizabeth Mpofu (born 1959), Zimbabwean farmer and activist
- Mpumi Mpofu, South African Secretary of Defence
- Nkosana Mpofu (born 1988), Creative
- Obert Mpofu, Zimbabwean politician
- Sizwe Mpofu-Walsh (born 1989), South African author, musician, activist and son of Dali Mpofu
- Tafadzwa Mpofu (born 1985), Zimbabwean cricketer
- Lunathi Mpofu, South African actress
- Oris Mpofu, South African actor
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