The following highways are numbered 278:

Canada

• Manitoba Provincial Road 278

Japan

• Japan National Route 278

United States

• Interstate 278
• U.S. Route 278
• Arkansas Highway 278 (former)
• Florida State Road 278 (former)
• Georgia State Route 278
• K-278 (Kansas highway)
• Kentucky Route 278
• Maryland Route 278 (former)
• Minnesota State Highway 278 (former)
• Montana Secondary Highway 278
• New Mexico State Road 278
• Nevada State Route 278
• New York State Route 278
• Ohio State Route 278
• Pennsylvania Route 278 (former)
• Tennessee State Route 278
• Texas State Highway 278 (former)
  • Texas State Highway Spur 278
  • Farm to Market Road 278 (Texas)
• Utah State Route 278 (former)
• Virginia State Route 278
• Washington State Route 278