The following highways are numbered 161:

Canada

• New Brunswick Route 161
• Prince Edward Island Route 161
• Quebec Route 161

Costa Rica

• National Route 161

India

• National Highway 161

Ireland

• R161 road (Ireland)

Japan

• Japan National Route 161

United Kingdom

• A161 from Beckingham to Goole
• B161 road from A114 (Forest Gate) to A112 (near Leyton)

United States

• U.S. Highway 161 (former)
• Alabama State Route 161
• Arkansas Highway 161
• California State Route 161
• Connecticut Route 161
• Florida State Road 161
• Georgia State Route 161 (former)
• Illinois Route 161
• Indiana State Road 161
• Iowa Highway 161 (former)
• K-161 (Kansas highway)
• Kentucky Route 161
• Louisiana Highway 161
• Maine State Route 161
• Maryland Route 161
• Mississippi Highway 161
• Missouri Route 161
• Nevada State Route 161
• New Jersey Route 161
• New Mexico State Road 161
• New York State Route 161
• North Carolina Highway 161
• Ohio State Route 161
• Pennsylvania Route 161 (former)
• South Carolina Highway 161
• Tennessee State Route 161
• Texas State Highway 161
  • Texas State Highway Spur 161
• Utah State Route 161
• Virginia State Route 161
• Washington State Route 161
• West Virginia Route 161
• Wisconsin Highway 161
• Wyoming Highway 161

Territories

• Puerto Rico Highway 161