Ephraim Williams (1715–1755) was an American soldier; benefactor of Williams College in Massachusetts.
Ephraim Williams may also refer to:
- Ephraim Williams Sr. (1691 - 1754) was a colonial Massachusetts surveyor and land owner, instrumental in dispossession of the Mohicans.
- Ephraim S. Williams (1802–1890), mayor of Flint, Michigan
- Ephraim Williams (footballer) (1877–1954), Druids F.C. and Wales international footballer
- Ephraim "Eph" Williams, African American variety show proprietor; see Silas Green from New Orleans
- Ephraim Williams (mariner), 19th-century American sealer from Stonington, Connecticut, see Express Island
- Ephraim Williams, see wreck of the Ephraim Williams, a ship sunk off North Carolina in 1884
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