Cesc or CESC may refer to:
- Chamundeshwari Electricity Supply Corporation, an electricity supply company in Karnataka, India
- Calcutta Electric Supply Corporation, an electricity supply company in West Bengal, India
- Cesc Fàbregas, Spanish association football player
- Cesc Gay, Spanish screenwriter and director
- Cesc, Catalan comic writer and recipient of the Creus de Sant Jordi
- Corneal epithelial stem cells
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